Publications
Okihide Hikosaka
February 2008
Balleine BW, Delgado MR, Hikosaka O. (2007) The role of the dorsal striatum in reward and decision-making. J Neurosci. 2007 Aug 1;27(31):8161-5. (pdf)
Matsumoto M, Hikosaka, O. (2007) Lateral habenula as a source of negative reward signals in dopamine neurons. Nature doi:10.1038/nature05860.(pdf)
Hikosaka O. (2007) GABAergic output of the basal ganglia. Prog Brain Res. 2007;160:209-26. (pdf)
Hikosaka O. (2007) Basal ganglia mechanisms of reward-oriented eye movement. Ann N Y Acad Sci. 2007 May;1104:229-49. Epub 2007 Mar 14. (pdf)
Isoda M, Hikosaka O. (2007) Switching from automatic to controlled action by monkey medial frontal cortex. Nat Neurosci. Jan 21.(pdf)
Ding L, Hikosaka O. (2007) Temporal development of asymmetric reward-induced bias in macaques. J Neurophysiol. Jan; 97(1):57-61. (pdf)
Kobayashi S, Kawagoe R, Takikawa Y, Koizumi M, Sakagami M, Hikosaka O. (2007) Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward. Exp Brain Res. 176:341-355. (pdf)
Nakamura K, Hikosaka O. (2006) Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate. J Neurosci. Dec 13; 26(50):12885-95. (pdf)
Kobayashi S, Nomoto K, Watanabe M, Hikosaka O, Schultz W, Sakagami M. (2006) Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex.Neuron. 2006 Sep 21;51(6):861-70. (pdf)
Nakahara H, Nakamura K, Hikosaka O. (2006) Extended LATER model can account for trial-by-trial variability of both pre- and post-processes. Neural Netw. Oct;19(8):1027-46. (pdf)
Ding L, Hikosaka O. (2006) Comparison of reward modulation in the frontal eye field and caudate of the macaque. J Neurosci. 2006 Jun 21;26(25):6695-703. (pdf)
Watanabe K, Ikeda H, Hikosaka O. (2006) Effects of explicit knowledge of workspace rotation in visuomotor sequence learning.Exp Brain Res. Oct;174(4):673-8 (pdf)
Nakamura K, Hikosaka O. (2006) Role of dopamine in the primate caudate nucleus in reward modulation of saccades. J Neurosci. May 17; 26(20):5360-9. (pdf)
Hikosaka O, Nakamura K, Nakahara H. (2006) Basal ganglia orient eyes to reward.
J Neurophysiol. Feb; 95(2):567-84. (pdf)
Watanabe K, Hikosaka O. (2005) Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency. J Neurophysiol. Sep; 94(3):1879-87. (pdf)
Sakai K, Hikosaka O, Nakamura K. (2004) Emergence of rhythm during motor learning.
Trends Cogn Sci. Dec; 8(12):547-53. (pdf)
Takikawa Y, Kawagoe R, Hikosaka O (2004) A possible role of midbrain dopamine
neurons in short- and long-term adaptation of saccades to position-reward
mapping. J Neurophysiol 92:2520-2529.
Kawagoe R, Takikawa Y,
Hikosaka O (2004) Reward-predicting activity of
dopamine and caudate neurons - a possible mechanism of motivational control of
saccadic eye movement. J Neurophysiol 91:1013-1024.
Nakahara H, Itoh H, Kawagoe R, Takikawa Y, Hikosaka O (2004)
Dopamine neurons can represent context-dependent prediction error. Neuron
41:269-280.
Nomura Y, Fukuda
H, Terao Y, Hikosaka O, Segawa M (2003) Abnormalities of voluntary saccades in
Gilles de la Tourette's syndrome: pathophysiological
consideration. Brain Dev 25 Suppl 1:S48-54.(pdf)
Watanabe K, Lauwereyns J, Hikosaka O (2003) Neural correlates of rewarded and unrewarded eye movements
in the primate caudate nucleus. J Neurosci
23:10052-10057.
Ikeda T, Hikosaka O (2003). Reward-dependent gain
and bias of visual responses in primate superior colliculus.
Neuron 39: 693-700.
Sakai K, Kitaguchi K, Hikosaka O (2003)
Chunking during human visuomotor sequence learning.
Exp Brain Res 152:229-242.
Watanabe K, Lauwereyns J, Hikosaka O (2003)
Effects of motivational conflicts on visually elicited saccades in monkeys. Exp
Brain Res 152:361-367.
Itoh H, Nakahara H, Hikosaka
O,
Hikosaka O, Rand MK, Nakamura K, Miyachi S, Kitaguchi K, Sakai K,
Lu X, Shimo Y (2002b) Long-term retention of motor
skill in macaque monkeys and humans. Exp Brain Res
147:494-504.
Miyachi S, Hikosaka O,
Lu X (2002) Differential activation of monkey striatal
neurons in the early and late stages of procedural learning. Exp Brain Res 146:122-126.
Lauwereyns J, Watanabe K, Coe B, Hikosaka O (2002) A neural
correlate of response bias in monkey caudate nucleus. Nature 418:413-417.
Coe B, Tomihara K, Matsuzawa M, Hikosaka
O (2002) Visual and Anticipatory Bias in Three Cortical Eye Fields of the
Monkey during an Adaptive Decision-Making Task. J Neurosci
22:5081-5090.
Lu X, Matsuzawa
M, Hikosaka O (2002) A
neural correlate of oculomotor sequences in
supplementary eye field. Neuron 34:317-325.(pdf)
Nakahara H, Amari Si S, Hikosaka
O (2002) Self-organization in the basal ganglia with modulation of
reinforcement signals. Neural Comput 14:819-844.
Sato M, Hikosaka O (2002) Role of primate substantia
nigra pars reticulata in
reward-oriented saccadic eye movement. J Neurosci
22:2363-2373.
Kobayashi S, Lauwereyns J, Koizumi M, Sakagami
M, Hikosaka O (2002) Influence of reward expectation
on visuospatial processing in macaque lateral
prefrontal cortex. J Neurophysiol 87:1488-1498.
Takikawa Y, Kawagoe R, Hikosaka O (2002a) Reward-dependent spatial selectivity of
anticipatory activity in monkey caudate neurons. Journal of Neurophysiology 87:508-515.
Lauwereyns J, Takikawa Y,
Kawagoe R, Kobayashi S, Koizumi M, Coe B, Sakagami M, Hikosaka O (2002)
Feature-based anticipation of cues that predict reward in monkey caudate
nucleus. Neuron 33:463-473.
Takikawa Y, Kawagoe R, Itoh H, Nakahara H, Hikosaka O
(2002b) Modulation of saccadic eye movements by predicted reward outcome. Experimental Brain Research 142:284-291.
Nakahara H, Doya K, Hikosaka O (2001) Parallel cortico-bsal
ganglia mechanisms for acquisition and execution of visuomotor
seqeunces - A computational approach. Journal of
Cognitive Neuroscience 13: 1-22.
Sakagami M, Tsutsui
K-I, Lauwereyns J, Koizumi M, Kobayashi S, Hikosaka O (2001) A code for behavioral inhibition on the
basis of color, but not motion, in ventrolateral
prefrontal cortex of macaque monkey. J Neurosci 21:
4801-4808
Lauwereyns J, Sakagami M,
Tsutsui K-I, Kobayashi S, Koizumi M, Hikosaka O (2001) Responses to task-irrelevant visual
features by primate prefrontal neurons. J Neurophysiol
86: 2001-2010.
Shimo Y, Hikosaka
O (2001) Role of tonically active neurons in primate
caudate in reward-oriented saccadic eye movement. J Neurosci 21:
7804-7814.
Lauwereyns J, Koizumi M, Sakagami
M, Hikosaka O, Kobayashi S, Tsutsui
K (2000) Interference from irrelevant features on visual discrimination by
macaques (Macaca fuscata) : a
behavioral analogue of human stroop effect. Journal
of Experimental Psychology: Animal Behavior Processes 26: 352-357.
Rand MK, Hikosaka O, Miyachi S, Lu X, Nakamura K, Kitaguchi
K, Shimo Y (2000) Characteristics of sequential
movements during early learning period in monkeys. Exp Brain Res 131: 293-304.
Sakai K, Hikosaka O, Takino R, Miyauchi S, Nielsen M, Tamada T (2000) What and when: parallel and convergent
processing in motor control. J Neurosci 20:
2691-2700.
Sakai K, Hikosaka O, Miyauchi
S, Sasaki Y, Fujimaki N, Pütz
B (1999) Pre-SMA activation during sequence learning reflects visuo-motor association. J Neurosci
19:RC1: 1-6.
Nakamura K, Sakai K, Hikosaka
O (1999) Effects of local inactivation of monkey medial frontal cortex in
learning of sequential procedures.
J Neurophysiol 82: 1063-1068.
Sakai K, Hikosaka O, Miyauchi S, Takino R, Tamada T, Iwata NK, Nielsen M (1999) Neural representation
of a rhythm depends on its interval ratio. J Neurosci
19: 10074-10081.
Lu X, Hikosaka O, Miyachi S (1998) Role of monkey cerebellar
nuclei in skill for sequential movement. J Neurophysiol
79: 2245-2254.
Nakamura K, Sakai K, Hikosaka O
(1998) Neuronal activity in medial frontal cortex during learning of sequential
procedures. J Neurophysiol 80: 2671-2687.
Kawagoe R, Takikawa Y, Hikosaka O (1998) Expectation of reward modulates cognitive
signals in the basal ganglia. Nat Neurosci 5:
411-416.
Rand MK, Hikosaka O, Miyachi
S, Lu X, Miyashita K (1998) Characteristics of a long-term procedural skill in
the monkey. Exp Brain Res 118: 293-297.
Sakai K, Hikosaka O, Miyauchi
S, Takino R, Sasaki Y, Pütz
B (1998a) Transition of brain activation from frontal to parietal areas in visuo-motor sequence learning. J Neurosci
18: 1827-1840.
Sakai K, Takino R, Hikosaka
O, Miyauchi S, Sasaki Y, Pütz
B, Fujimaki N (1998b) Separate cerebellar
areas for motor control. NeuroReport 9: 2359-2363.(pdf)
Takikawa Y, Kawagoe R,
Miyashita N, Hikosaka O (1998) Presaccadic
omnidirectional burst activity in the basal
interstitial nucleus in the monkey cerebellum. Exp Brain Res
121: 442-450.
Terao Y, Fukuda H, Ugawa Y,
Hikosaka O, Hanajima R, Furubayashi T, Sakai K, Miyauchi
S, Sasaki Y, Kanazawa I (1998) Visualization of the information flow through
human oculomotor cortical regions by transcranial magnetic stimulation. J Neurophysiol
80: 936-946.
Horikawa HPM, Nakazato T, Hikosaka O (1997) Duration of catalepsy correlates with
increased intrastriatal sulpiride.
European Journal of Pharmacology 326: 15-21.
Miyachi S, Hikosaka O,
Miyashita K, Karádi Z, Rand MK (1997b) Differential
roles of monkey striatum in learning of sequential hand movement. Exp Brain Res 115: 1-5.
Nakahara H, Doya K, Hikosaka
O, Nagano S (1997b) Multiple representations in the
basal ganglia loops for sequential decision making. Technical Report of IEICE
NC97-24: 97-104.
Shimojo S, Miyauchi S, Hikosaka O (1997) Visual motion sensation yielded by
non-visually driven attention. Vision Res 37:
1575-1580.
Hikosaka O, Sakai K, Miyauchi
S, Takino R, Sasaki Y, Pütz
B (1996) Activation of human presupplementary motor
area in learning of sequential procedures: A functional MRI study. J Neurophysiol 76: 617-621(pdf).
Kojima J, Matsumura M, Togawa M, Hikosaka
O (1996) Tonic activity during visuo-oculomotor
behavior in the monkey superior colliculus. Neurosci Res 26: 17-28.
Miyashita K, Rand MK, Miyachi S, Hikosaka
O (1996a) Anticipatory saccades in sequential procedural learning in monkeys. J
Neurophysiol 76: 1361-1366.
Miyashita N, Hikosaka O (1996) Minimal synaptic delay
in the saccadic output pathway of the superior colliculus
studied in awake monkey. Exp Brain Res
112: 187-196.
Kato M, Hikosaka O (1995) Function of the indirect pathway
in the basal ganglia oculomotor system: visuo-oculomotor activities of external
pallidum neurons. In: Age-Related Dopamine-Deficient Disorders (Segawa M,
Nomura Y, eds), pp.
178-187. Basal: Karger.
Hikosaka O, Rand MK, Miyachi
S, Miyashita K (1995b) Learning of sequential movements in the monkey - Process
of learning and retention of memory. J Neurophysiol
74: 1652-1661.
Iwamura Y, Tanaka M, Hikosaka
O, Sakamoto M (1995) Postcentral neurons of alert
monkeys activated by the contact of the hand with objects other than the
monkey's own body. Neurosci Lett
186: 127-130.
Kato M, Miyashita N, Hikosaka O, Matsumura M, Usui S, Kori A (1995) Eye movements
in monkeys with local dopamine depletion in the caudate nucleus. I. Deficits in
spontaneous saccades. J Neurosci 15: 912-927.
Kori A, Miyashita N, Kato M, Hikosaka
O, Usui S, Matsumura M (1995) Eye movements in
monkeys with local dopamine depletion in the caudate nucleus. II. Deficits in
voluntary saccades. J Neurosci 15: 928-941.
Miyashita N, Hikosaka O, Kato M (1995b) Visual hemineglect induced by unilateral striatal
dopamine deficiency in monkeys. NeuroReport 6:
1257-1260.
Hikosaka O, Rand MK, Miyachi S, Miyashita K (1995c) Procedural
learning in the monkey. In: Functions of the Cortico-Basal Ganglia Loop (Kimura
M, Graybiel AM,
eds), pp. 18-30.
Hikosaka O (1994) Role of basal ganglia in control of innate
movements, learned behavior and cognition - a hypothesis. In: The Basal Ganglia
IV: New Ideas and Data on Structure and Function (Percheron G, McKenzie JS,
Féger J, eds), pp.
589-596.
Hikosaka O, Miyauchi S, Shimojo S (1993c) Focal visual attention produces illusory
temporal order and motion sensation. Vision Res 33:
1219-1240.
Hikosaka O, Miyauchi S, Shimojo S (1993e) Voluntary and stimulus-induced attention
detected as motion sensation. Perception 22: 517-526.(pdf)
Hikosaka O, Sakamoto M, Miyashita N (1993f) Effects
of caudate nucleus stimulation on substantia nigra cell activity in monkey. Exp Brain Res 95: 457-472.
Iwamura Y, Tanaka M, Sakamoto M, Hikosaka
O (1993) Rostrocaudal gradients in the neuronal
receptive field complexity in the finger region of the alert monkey's postcentral gyrus. Exp Brain Res 92: 360-368.
Matsumura M, Kojima J, Gardiner TW, Hikosaka
O (1992) Visual and oculomotor functions of monkey subthalamic nucleus. J Neurophysiol
67: 1615-1632.
Usui S, Fukuda H, Hikosaka
O (1990a) Spontaneous saccades in MPTP-induced hemi-parkinsonian
monkeys. Clin Neurol 30:
1181-1189.
Hikosaka O, Sakamoto M, Usui
S (1989a) Functional properties of monkey caudate neurons. I. Activities
related to saccadic eye movements. J Neurophysiol 61:
780-798.
Hikosaka O, Sakamoto M, Usui
S (1989b) Functional properties of monkey caudate neurons. II. Visual and
auditory responses. J Neurophysiol 61: 799-813.
Hikosaka O, Sakamoto M, Usui
S (1989c) Functional properties of monkey caudate neurons. III. Activities
related to expectation of target and reward. J Neurophysiol
61: 814-832.
Sakamoto M, Hikosaka O (1989) Eye movements induced
by microinjection of GABA agonist in the rat substantia
nigra pars reticulata. Neurosci Res 6: 216-233.
Hikosaka O, Sakamoto M (1987) Dynamic characteristics
of saccadic eye movements in the albino rat. Neurosci
Res 4: 304-308.
Hikosaka O, Wurtz RH (1986)
Saccadic eye movements following injection of lidocaine
into the superior colliculus. Exp Brain Res 61: 531-539.
Hikosaka O, Sakamoto M (1986a) Cell activity in
monkey caudate nucleus preceding saccadic eye movements. Exp Brain Res 63: 659-662.
Hikosaka O, Sakamoto M (1986b) Neural
activities in the monkey basal ganglia related to attention, memory and
anticipation. Brain Dev 8: 454-462.
Hikosaka O, Wurtz RH
(1985a) Modification of saccadic eye movements by GABA-related substances. I.
Effect of muscimol and bicuculline
in the monkey superior colliculus. J Neurophysiol 53: 266-291.
Hikosaka O, Wurtz RH
(1985b) Modification of saccadic eye movements by GABA-related substances. II.
Effects of muscimol in monkey substantia
nigra pars reticulata. J Neurophysiol 53: 292-308.
Hikosaka O, Tanaka M, Sakamoto M, Iwamura
Y (1985) Deficits in manipulative behaviors induced by local injections of muscimol in the first somatosensory
cortex of the conscious monkey. Brain Res 325: 1-2.
Iwamura Y, Tanaka M, Sakamoto M, Hikosaka
O (1985b) Diversity in receptive field properties of vertical neuronal arrays
in the crown of the postcentral gyrus
of the conscious monkey. Exp Brain Res 58: 400-411.
Iwamura Y, Tanaka M, Sakamoto
M, Hikosaka O (1985d) Vertical neuronal arrays in the
postcentral gyrus signaling
active touch: A receptive field study in the conscious monkey. Exp Brain Res 58: 412-420.
Hikosaka O, Wurtz RH
(1983a) Effects on eye movements of a GABA agonist and antagonist injected into
monkey superior colliculus. Brain Res
272: 368-372.
Hikosaka
O, Wurtz RH (1983b) Visual and oculomotor
functions of monkey substantia nigra
pars reticulata. I. Relation of visual and
auditory responses to saccades. J Neurophysiol 49:
1230-1253.
Hikosaka
O, Wurtz RH (1983c) Visual and oculomotor
functions of monkey substantia nigra
pars reticulata. II. Visual responses related
to fixation of gaze. J Neurophysiol 49: 1254-1267.
Hikosaka
O, Wurtz RH (1983d) Visual and oculomotor
functions of monkey substantia nigra
pars reticulata. III. Memory-contingent visual
and saccade responses. J Neurophysiol 49: 1268-1284.
Hikosaka
O, Wurtz RH (1983e) Visual and oculomotor
functions of monkey substantia nigra
pars reticulata. IV. Relation of substantia nigra to superior colliculus. J Neurophysiol 49:
1285-1301.
Iwamura Y, Tanaka M, Sakamoto M, Hikosaka
O (1983a) Converging patterns of finger representation and complex response
properties of neurons in area 1 of the first somatosensory
cortex of the conscious monkey. Exp Brain Res 51:
327-337.
Iwamura Y, Tanaka M, Sakamoto M, Hikosaka
O (1983b) Functional subdivisions representing different finger regions in area
3 of the first somatosensory cortex of the conscious
monkey. Exp Brain Res 51: 315-326.
Hikosaka O, Igusa Y (1980)
Axonal projection of prepositus hypoglossi
and reticular neurons in the brainstem of the cat. Exp Brain Res 39: 441-451.
Hikosaka
O, Igusa Y, Imai H (1980a) Inhibitory connections of nystagmus-related reticular burst neurons with neurons in
the abducens, prepositus hypoglossi and vestibular nuclei in the cat. Exp
Brain Res 39: 301-311.
Hikosaka O, Nakao S, Shimazu H (1980b) Postsynaptic inhibition underlying spike
suppression of secondary vestibular neurons during quick phases of vestibular nystagmus. Neurosci Lett 16: 21-26.
Ishimine S, Hikosaka O,
Nakamura Y (1980) Spatio-temporal patterns of pre-
and postsynaptic inhibition induced by primary afferent activation in the
trigeminal sensory nucleus in cats. Exp Brain Res 40:
154-163.
Iwamura Y,
Tanaka M, Hikosaka O (1980) Overlapping
representation of fingers in area 2 of the monkey somatosensory
cortex of the conscious monkey. Brain Res 197:
516-520.
Hikosaka O, Igusa Y, Imai H
(1978a) Firing pattern of prepositus hypoglossi and adjacent reticular neurons related to
vestibular nystagmus in the cat. Brain Res 144: 395-403.
Hikosaka O, Igusa Y, Nakao S, Shimazu H (1978b) Direct inhibitory synaptic linkage of pontomedullary
reticular burst neurons with abducens motoneurons in the cat. Exp Brain Res
33: 337-352.
Hikosaka O, Maeda M, Nakao
S, Shimazu H, Shinoda Y
(1977) Presynaptic impulses in the abuducens nucleus and their relation to postsynaptic
potentials in motoneurons during vestibular nystagmus. Exp Brain Res 27:
355-376.
Hikosaka O, Kawakami T (1977) Inhibitory reticular
neurons related to the quick phase of vestibular nystagmus
- their location and projection. Exp Brain Res 27:
377-396.
Hikosaka O, Kawakami T (1976) Inhibitory interneurons in the reticular formation and their relation
to vestibular nystagmus. Brain Res
117: 513-518.
Hikosaka O, Maeda M (1973) Cervical
effects on abducens motoneurons
and their interaction with vestibulo-ocular reflex.
Exp Brain Res 18: 512-530.